The scientific journal "Proceedings of Higher Educational Institutions. Volga Region. Medical Sciences" (No. 1, 2025), published by Penza State University, features an article by Professor Alexey Sergeevich Ryazanov titled "Personalized Therapy of Cardiovascular Diseases in Outpatient Practice." The article delves into the key aspects of an individualized approach to managing patients with cardiovascular diseases in outpatient settings. The author highlights that personalized medicine, grounded in the analysis of a patient’s unique characteristics, enhances prevention and treatment strategies. Ryazanov discusses the use of validated scales and imaging techniques for assessing cardiovascular risk, as well as the selection of target blood pressure, lipid, and glucose levels based on the patient’s profile. Special focus is placed on tailoring drug therapy considering comorbidities and drug interactions, alongside improving patient adherence through educational programs and patient-centered counseling. The article underscores the importance of a multidisciplinary approach and continuity of care. In conclusion, the author asserts that personalized medicine in outpatient practice improves the effectiveness and safety of treatment.